2 edition of DNA topoisomerase II[alpha] found in the catalog.
DNA topoisomerase II[alpha]
John Peter McPherson
Written in English
|The Physical Object|
|Number of Pages||177|
The type II topoisomerases are important enzymes that are involved in maintaining the structure of DNA and chromosome segregation during both replication and transcription of DNA. One of these enzymes, topoisomerase II alpha, is involved in the replication of DNA and cell proliferation, and is highly expressed in rapidly dividing cancer cells. UNIVERSITY OF CALGARY Characterization of Salicylates as Novel Catalytic Inhibitors of Human DNA Topoisomerase II Alpha by Jason Theodore Bau A THESIS SUBMITTED TO THE FACULTY OF GRADUATE STUDIES IN PARTIAL FULFILMENT OF THE REQUIREMENTS FOR THE DEGREE OF DOCTOR OF PHILOSOPHY DEPARTMENT OF MEDICAL .
The Ecoli topoisomerase I is a holoenzyme with three Zn (II) atoms in the tetracysteine motifs near its carboxy terminus. It is 97 kDa in weight. Topoisomerase I has several unusual features. It does not need ATP hydrolyzing to catalyze the topological rearrangement of DNA. The exiting feature of the topoisomerase I is, it is a fully functional Missing: book. - type II topoisomerase in E. Coli-can introduce negative supercoils into the DNA ahead of the replication fork. - in the absence of DNA gyrase, strand separation would cause overwinding of the DNA ahead of the replication fork, a generating positive supercoils that would hinder DNA . Mammals have two isoenzymes topII-alpha and beta. In the presence of magnesium ions, the tyrosine from each top II monomer attacks the phosphodiester bond four bases apart on opposite strands of the G duplex and becomes covalently linked to the 5' end of the broken DNA.
Topoisomerase II alpha (TOP2A) is encoded by the TOP2A gene located on chromosome 17qq It is a key nuclear enzyme for controlling of topological states of DNA by generating transient breakage in double-stranded DNA; therefore it is involved in processes such as DNA replication and transcription, and chromosome formation, enrichment, and Cited by: 7. Watt and Hickson () reviewed in extenso the structure and function of type II DNA topoisomerases. Mondal and Parvin () demonstrated that DNA topoisomerase II-alpha is associated with the pol II holoenzyme and is a required component of chromatin-dependent coactivation. Specific inhibitors of topoisomerase II blocked transcription on chromatin . DNA Topoisomerase (ATP Hydrolysing) Topoisomerase II is an essential enzyme that acts as a dimer to relieve superhelical stress, and the topoisomerase II poisons, which are used to treat nearly one-half of all cancers, lock the complex in the open-gate conformation, creating a persistent protein-associated DSB .
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SyntaxTextGen not activatedDNA topoisomerases are a group of enzymes involved in the topology of DNA pdf critical cellular processes including replication, recombination, transcription, and repair systems by transiently breaking one or two strands of DNA (Bodley and Liu, Cited by: DNA topoisomerase II alpha is the major chromosome protein recognized by the mitotic phosphoprotein download pdf MPM Proc Natl Acad Sci U S A.
Sep 15; 90 (18)– [PMC free article] Takano H, Kohno K, Ono M, Uchida Y, Kuwano M. Increased phosphorylation of DNA topoisomerase II in etoposide-resistant mutants of human cancer KB Cited by: Type II topoisomerases (TOP2s) resolve the topological problems of Ebook by transiently cleaving both strands of a DNA duplex to form a cleavage complex through which another DNA segment can be transported.
Several widely prescribed anticancer drugs in Cited by: